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Suppose you wanted to do a study of diet and nutrition, with thousands of participants randomly assigned to follow one meal plan or another for years as their health was monitored? In the real world, studies like these are nearly impossible. And one of the biggest of those mysteries Looking 4 head maybe more salt and its relationship to health.

They want to conduct an Looking 4 head maybe more trial of salt intake with incarcerated inmates, whose diets could be tightly controlled. The mofe, who recently proposed the idea in the journal Hypertensionsay they are not only completely serious — they are optimistic it will happen. Sign up for the Science Times newsletter. Using inmates as study subjects is controversial, to say the least.

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History is laden with horror stories. In the s, prisoners were deliberately infected with malaria.

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In the s, inmates were infected with hepatitis. The point of the proposed study is to put an hesd to decades of scientific disagreement over salt and its benefits and hazards. On one side are researchers who say Americans eat too much sodium and that it is harming their health. For healthy people, the American Heart Association recommends 2, milligrams a Looking 4 head maybe more. But for those with high blood pressure, the ideal amount is 1, milligrams, or less than half a teaspoon.

Low-salt diets lower blood pressure, so a very low-salt diet ought to result in less cardiovascular disease and fewer deaths. They worry that very low sodium levels can actually make health worse, citing studies that found higher death rates Looking 4 head maybe more rates of heart attacks and strokes in people following low-sodium diets.

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And the stubborn resistance of people told to consume less salt indicates to some experts that humans crave salt for a Lookkng — they need it for their health.

Average sodium consumption in the United States and in many other countries has not budged for decades. It is about 3, milligrams a day.

For years, medical experts, including a group Looking 4 head maybe more produced a report for the Institute of Medicine on dietary sodiumhave called Looking 4 head maybe more a randomized clinical trial of sodium in the diet that looked at outcomes like deaths and strokes, not at risk factors like blood pressure. But there has never been such a trial, and that has made this subject a minefield for scientists and consumers alike.

Daniel W. Jones, a professor of medicine and physiology at the University of Mississippi School of Medicine and former president of the American Heart Moer, was alarmed by the bitter arguments and increasingly personal disputes between researchers who disagree about salt.

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So he mayne senior medical scientists on both sides of the debate to meet in Jackson, Miss. Jones, who believes low-salt diets are healthier. Jones said.

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Those he invited, six in all, Lookig to sit down to hash out their differences at the university in Jackson, Miss. He later invited two other researchers — Dr.

Eric Peterson, a clinical trials expert at Duke University, and Dr. Robert Califf, also at Duke and a former head of the Food and Drug Administration — to weigh in on the final paper.

Jones and Dr. David McCarron, a nutrition researcher at heaf University of California, Davis, who worries that low-sodium diets are dangerous to health, led the discussion.

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They began by putting the Institute of Medicine report before the group and highlighting the recommendation that there be a randomized clinical trial in a population whose diet can be controlled. And if the answer is yes, what is the ideal population?

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Jones said, recalling the conversation. For two days, the group debated and mulled over various options.

Conduct the study among military personnel? Too young.

Nursing homes? Too many residents are already prescribed low-sodium diets.

So suppose you do the study in prisons, said Dr. Is the research supposed to benefit the prisoners or just the population in general?

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If the prisoners would not benefit, the study would be unethical. People who are not incarcerated can choose how much sodium they consume, but prisoners cannot — they eat whatever the facility provides.

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If there is uncertainty about the ideal amount of sodium, the experts concluded, ,aybe would benefit from a study that settled the matter. He also teaches at a nearby maximum security prison.

Howard said in a telephone interview.

But, Dr. He added that many incarcerated people have outgrown their criminal pasts and have a desire to help society.

Macklin, in a telephone interview, also said many prisoners would be happy to jump in. She has taught in a maximum security facility and has studied the ethics of doing research in prisons.

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Macklin said. Prison administrators have told Dr. Jones they would be willing to consider a proposal for a randomized trial of salt. He also will be speaking to the American Civil Liberties Union, which runs a project on inmate rights, to explain the study and why it addresses important questions for prisoners.

The Looking 4 head maybe more is to start with a pilot project Horny wives in Alderton prisoners aged 55 and over. That would be followed by a large trial lasting about five years and involving 10, to 20, prisoners in that age group. The researchers plan to request funding from the National Institutes of Health.

Of course, Dr. Jones said, the trial at this point is just a proposal. We came together to find a solution. Gina Kolata writes about science and medicine.

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Maybe Prisoners. Earlier reporting on the salt debate. The best option, by far, seemed to be people who were incarcerated.

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But it Loooking amazing. A version of this article appears in print onon Page D3 of the New York edition with the headline: Looking to Prison for a Health Study. Open in the app.